Dysregulation of protein degradation and alteration of secretome in α-synuclein-exposed astrocytes: implications for dopaminergic neuronal dysfunction
The initial protective action of astrocytes in clearing and degrading extracellular α-synuclein is severely compromised at latter stages, leading to astrocytic dysfunction and impairing neuron-glia cross-talk. This study underscores the criticality of integrating astrocytes into treatment paradigms in synucleinopathies.
Authors
- Aishwarya Raj (ORCID: https://orcid.org/0000-0001-8069-0280)
- Indrani Datta (ORCID: https://orcid.org/0000-0001-8864-473X)
- Vikram Venkappayya Holla (ORCID: https://orcid.org/0000-0002-3634-2219)
- Ravi Yadav (ORCID: https://orcid.org/0000-0003-2879-0465)
- Roon Banerjee
- Nitish Kamble
- Pramod Kumar Pal
Institutions
- National Institute of Mental Health and Neurosciences (IN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-12-02
- DOI
- https://doi.org/10.1186/s12964-024-01928-9
- Citations
- 6
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.21