Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors
Our data provide a comprehensive resource of genetic and chemical dependencies in ATRTs, which will inform further preclinical evaluation of novel targeted therapies for this tumor entity. Furthermore, this study reveals a unique mechanism of cell cycle inhibition as the basis for tumor suppressive functions of AMBRA1.
Authors
- Federica Piccioni (ORCID: https://orcid.org/0000-0003-1210-3210)
- Daniel Merk (ORCID: https://orcid.org/0000-0003-2935-6919)
- Mohamed Ali Jarboui (ORCID: https://orcid.org/0000-0002-5203-235X)
- Manfred Claassen (ORCID: https://orcid.org/0000-0002-4583-9083)
- Jakob Admard (ORCID: https://orcid.org/0000-0003-0466-582X)
- Cristiana Roggia (ORCID: https://orcid.org/0000-0002-6097-2536)
- Bianca Walter (ORCID: https://orcid.org/0000-0001-9734-4843)
- Lara Annina Haeusser (ORCID: https://orcid.org/0000-0002-3288-4280)
- Sepideh Babaei (ORCID: https://orcid.org/0000-0002-5957-6907)
- Michael Spohn
- Jens Schittenhelm (ORCID: https://orcid.org/0000-0002-9168-6209)
- Marcos Soares Tatagiba (ORCID: https://orcid.org/0000-0002-1627-9937)
- Nicolas Casadei (ORCID: https://orcid.org/0000-0003-2209-0580)
- Nicole S. Persky (ORCID: https://orcid.org/0000-0002-9948-2761)
- Franziska Klose
- Markus F. Templin (ORCID: https://orcid.org/0000-0002-6569-6489)
- Foteini Tsiami (ORCID: https://orcid.org/0009-0001-6070-0434)
- Aaron Stahl (ORCID: https://orcid.org/0000-0003-3616-9564)
- Ulrich Schüller (ORCID: https://orcid.org/0000-0002-8731-1121)
- Anna Lechado‐Terradas (ORCID: https://orcid.org/0000-0003-2650-965X)
- David E. Root (ORCID: https://orcid.org/0000-0001-5122-861X)
- Philipp J. Kahle (ORCID: https://orcid.org/0000-0002-8587-1731)
- Ghazaleh Tabatabai (ORCID: https://orcid.org/0000-0002-3542-8782)
- Jens D. Maile
- Sophie Hirsch (ORCID: https://orcid.org/0000-0002-1012-0853)
- Stephan Singer (ORCID: https://orcid.org/0000-0003-4775-6609)
Institutions
- Broad Institute (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- German Center for Neurodegenerative Diseases (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Kinderkrebs-Zentrum Hamburg (DE)
- Natural and Medical Sciences Institute (DE)
- University Children's Hospital Tübingen (DE)
- Bernstein Center for Computational Neuroscience Tübingen (DE)
- Hertie Institute for Clinical Brain Research (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Genome biology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1186/s13059-024-03438-w
- Citations
- 5
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Adolf Leuze Stiftung
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- Universitätsklinikum Tübingen