Systematic drug screening and target analysis identify digitoxin as a potential therapy for uveal melanoma
Given UVM's limited options, our study highlights the potential of digitoxin as a promising novel therapeutic agent for this aggressive and rare ocular cancer. Our comprehensive approach is effective in identifying the potent, cancer-specific therapeutic agents from herbal plants.
Authors
- Zhengtao Xiao (ORCID: https://orcid.org/0000-0002-5535-5381)
- Chao Huang (ORCID: https://orcid.org/0000-0002-6951-8137)
- Jing Chen (ORCID: https://orcid.org/0009-0002-9889-0306)
- Yuhan Li (ORCID: https://orcid.org/0000-0002-5507-2162)
- Min Gao (ORCID: https://orcid.org/0000-0003-2106-0267)
- Yanan Zhu
- Hui Zhang (ORCID: https://orcid.org/0000-0002-9065-6956)
- Wei Zhao (ORCID: https://orcid.org/0000-0002-9841-8063)
- Zhenni Liu
- Huilin Liu (ORCID: https://orcid.org/0000-0001-5193-053X)
Institutions
- Northwest Women's and Children's Hospital (CN)
- Cell Technology (China) (HK)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Northwest Normal University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1111/bph.17405
- Citations
- 3
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Natural Science Foundation of China