Human subjects with impaired beta-cell function and glucose tolerance have higher levels of intra-islet intact GLP-1
Our data show that development of glucose intolerance and beta cell dysfunction are significantly associated with increased levels of intra-islet intact GLP-1, a potentially beneficial adaptation of the paracrine regulation of insulin secretion in type 2 diabetes.
Authors
- Giuseppe Quero (ORCID: https://orcid.org/0000-0002-0001-9479)
- Enrico Celestino Nista
- Antonio Gasbarrini (ORCID: https://orcid.org/0000-0002-6230-1779)
- Gea Ciccarelli (ORCID: https://orcid.org/0009-0001-3621-6298)
- Sergio Alfieri (ORCID: https://orcid.org/0000-0002-7813-4426)
- Gianfranco Di Giuseppe (ORCID: https://orcid.org/0000-0003-4506-5193)
- Laura Soldovieri (ORCID: https://orcid.org/0009-0001-3315-0406)
- Michela Brunetti (ORCID: https://orcid.org/0009-0008-0139-4749)
- Pietro Manuel Ferraro (ORCID: https://orcid.org/0000-0002-1379-022X)
- Teresa Mezza (ORCID: https://orcid.org/0000-0001-5407-9576)
- Vincenzo Tondolo (ORCID: https://orcid.org/0000-0003-0256-3766)
- Andrea Giaccari (ORCID: https://orcid.org/0000-0002-7462-7792)
- Alfredo Pontecorvi (ORCID: https://orcid.org/0000-0003-0570-6865)
- Andrea Mari (ORCID: https://orcid.org/0000-0002-1436-5591)
- Nicolai J Wewer Albrechtsen (ORCID: https://orcid.org/0000-0003-2730-6301)
- Jens J Holst
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Novo Nordisk Foundation (DK)
- Bispebjerg Hospital (DK)
- Agostino Gemelli University Polyclinic (IT)
- Copenhagen University Hospital (DK)
- Centro Clinico Nemo (IT)
- Neuroscience Institute (IT)
- National Research Council (IT)
Publication Details
- Journal
- Metabolism
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.metabol.2024.156087
- Citations
- 5
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- European Foundation for the Study of Diabetes
- Ministero della Salute
- Università Cattolica del Sacro Cuore
- Novo Nordisk Fonden
- Bispebjerg Hospital