Antibacterial <i>ent</i> -trachyloban-19-oic acid and other constituents from <i>Croton kinondoensis</i> G.W. Hu, Ngumbau & Q.F. Wang
Phytochemical analysis of the twigs and leaves of <i>Croton kinondoensis</i>, endemic to Kenya, yielded known compounds 3-(3',4'-dimethoxyphenyl)-prop-1-ene (<b>1)</b>, 3-(3',4'-dimethoxyphenyl)-propenal (<b>2</b>), lupeol (<b>3</b>) and <i>ent</i>-trachyloban-19-oic acid (<b>4</b>), and a tentatively new <i>ent</i>-clerodane diterpenoid, crotokinondoenolide (<b>5</b>). <i>ent</i>-Trachy-loban-19-oic acid (<b>4</b>) showed good activity against a panel of drug-resistant strains of <i>Staphylococcus aureus</i> and <i>Enterococcus</i> spp with MIC -values of 25 <i>µ</i>g/mL.
Authors
- Eduard Mas‐Claret (ORCID: https://orcid.org/0000-0003-4016-6649)
- Cristina D. Cruz (ORCID: https://orcid.org/0000-0003-4655-8563)
- Päivi Tammela (ORCID: https://orcid.org/0000-0003-4697-8066)
- Thomas A. K. Prescott (ORCID: https://orcid.org/0000-0002-3039-7067)
- Nicholas J. Sadgrove (ORCID: https://orcid.org/0000-0001-7593-1289)
- Moses Kiprotich Langat (ORCID: https://orcid.org/0000-0001-8079-7774)
- Sianne Schwikkard
- Mona Diri
Institutions
- University of Helsinki (FI)
- Kingston University London (GB)
- University of Johannesburg (ZA)
- Royal Botanic Gardens, Kew (GB)
- Kingston University (US)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1080/14786419.2024.2434132
- Citations
- 2
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article
- Field-Weighted Citation Impact
- 0.47