Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity
This study showed that ISL may exert cardioprotective role restoring BNIP3-mediated mitophagy by targeting TRDMT1 to alleviate DOX-induced macro-autophagy-dependent protein homeostasis and acquired blocking of mitophagy, providing a new idea for the clinical treatment of DIC.
Authors
- Jiaqi Fu (ORCID: https://orcid.org/0000-0003-0081-6133)
- Manya Yu
- Cheng Li (ORCID: https://orcid.org/0000-0001-7912-0643)
- Runjie Sun (ORCID: https://orcid.org/0000-0001-6924-4140)
- Suzhen Li
- Xing Cui (ORCID: https://orcid.org/0000-0002-8771-5898)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-7693-6388)
- Muyun Wu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.phymed.2024.156293
- Citations
- 15
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 3.51