TRPM7 contributes to pyroptosis and its involvement in status epilepticus
TRPM7 contributes to pyroptosis in SE, establishing a positive feedback loop involving the p-STAT3/TRPM7/Zn<sup>2+</sup>/p-STAT3 signaling pathway. Findings in this study raise the possibility that targeting TRPM7 and NLRP3 represents a promising therapeutic approach for SE.
Authors
- Wuyang Wang (ORCID: https://orcid.org/0000-0003-1875-5463)
- Feng Guo
- Jiahe Zheng (ORCID: https://orcid.org/0000-0003-2057-4776)
- Jian Shi (ORCID: https://orcid.org/0000-0002-6784-0026)
- Jingjing Duan (ORCID: https://orcid.org/0000-0003-2716-2627)
- Zhiyi Yu (ORCID: https://orcid.org/0000-0001-6227-0610)
- Jianjun Xu (ORCID: https://orcid.org/0000-0002-1855-8462)
- Reinhold Penner (ORCID: https://orcid.org/0000-0002-5366-1537)
- Tomasz Boczek (ORCID: https://orcid.org/0000-0002-7654-9011)
- Meixuan Li (ORCID: https://orcid.org/0000-0003-1740-9366)
- Hongyue Liang (ORCID: https://orcid.org/0000-0001-9935-7779)
- Andrea Fleig (ORCID: https://orcid.org/0000-0001-8396-7249)
- Ruixue Shi
- Naining Zhang
- Corey R. Seehus (ORCID: https://orcid.org/0000-0002-8647-8579)
- Xin Tong (ORCID: https://orcid.org/0000-0003-1340-0823)
- Dongyi Zhao (ORCID: https://orcid.org/0000-0001-7209-6185)
- Yulu Meng
- Tong Yu (ORCID: https://orcid.org/0000-0002-6960-3569)
- Xiaoxue Xu (ORCID: https://orcid.org/0000-0003-1831-3657)
- Sayuri Suzuki (ORCID: https://orcid.org/0000-0001-5921-7106)
- Weidong Zhao
- Jialu Wang
Institutions
- Kagoshima University (JP)
- University of Hawaiʻi at Mānoa (US)
- Boston Children's Hospital (US)
- University of Hawaii System (US)
- Nanchang University (CN)
- Shandong University (CN)
- Xuzhou Medical College (CN)
- Cancer Center of Hawaii (US)
- Fourth Affiliated Hospital of China Medical University (CN)
- Queen's Medical Center (US)
- Medical University of Lodz (PL)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1186/s12974-024-03292-4
- Citations
- 11
- Primary Topic
- Magnesium in Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 3.41
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province