Alzheimer's disease drug development in an evolving therapeutic landscape
The Alzheimer's Association Research Roundtable (AARR) convened leaders from industry and academia, as well as patients, clinicians, and government and regulatory agency scientists to discuss the topic, "Alzheimer's Disease Drug Development in an Evolving Therapeutic Landscape."While recently approved amyloid-targeting therapies show great promise in providing clinically meaningful outcomes for patients and families, additional treatments, and a better understanding of dosing and administration of these approved treatments, are needed to further slow and eventually prevent clinical decline in AD.Approved therapies will impact many aspects of clinical trial design including the use of placebo-controls, participant re-enrollment, safety monitoring, as well as biomarker selection.This exciting new era in AD research represents a hopeful future for clinicians, patients, and their care partners.
Authors
- Christopher J. Weber
- Adam Fleisher (ORCID: https://orcid.org/0000-0002-2556-0878)
- Paul Maruff (ORCID: https://orcid.org/0000-0002-6947-9537)
- Stacie Weninger
- Teresa León (ORCID: https://orcid.org/0000-0001-5171-4159)
- Sheila Seleri
- David S. Miller (ORCID: https://orcid.org/0000-0002-4633-2487)
- Marı́a C. Carrillo
- Michael C. Irizarry (ORCID: https://orcid.org/0000-0002-0246-2511)
Institutions
- Alzheimer's Association (US)
- Eli Lilly (United States) (US)
- Novo Nordisk (Denmark) (DK)
- Connecticut Sea Grant (US)
- Eisai (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/trc2.70015
- Citations
- 2
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.72