Study of Uric Acid Level in Newly Diagnosed Hypertensive Patients in Tertiary Care Centre, Barabanki

Background: The "quiet executioner" moniker for hypertension (HTN) comes from the fact that the condition often goes undiagnosed and unnoticed by its victims. The presence of high amounts of uric acid can cause an overexpression of both of these vasoconstrictor molecules, leading to the development of hypertension. Additionally, uric acid can mediate the onset of hypertension via a crystal - dependent mechanism. Evidence of monosodium urate deposits has been reported in various organs and tissues, including the renal medulla, heart valves, arteries, and atherosclerotic plaque. Aim: To study association between newly diagnosed hypertensive patients and their serum uric acid levels. Materials and Method: The study conducted at Dr KNS Memorial Institute of Medical Sciences, Barabanki involved patients with newly diagnosed hypertension and normotensive individuals. The research was a case - control study that lasted from August 2022 to February 2024, with a sample size of 150 (75 cases and 75 controls). Upon obtaining informed consent, The patients underwent investigations for systolic and diastolic blood pressure, as well as serum uric acid levels. Guidelines were followed for measuring blood pressure, including posture, avoidance of caffeine and smoking, and ensuring a quiet, warm setting. Results: Study suggestive of Grade 1 hypertension (40%) was common grade reported in our study. Apart from this; high normal (32%) and grade 2 (28%) was also reported. The mean value of lipid profile parameters like total cholesterol (195.07 v/s 171.09; p<0.001); LDL (107.40 v/s 94.69; p<0.001) and triglyceride (153.01 v/s126.36; p<0.001) was significantly higher in cases as compared to control. There was no significant difference in mean value of HDL between cases and control (46.43 v/s 44.72; p=0.407). Among hypertension cases - 25.3% had hyperuricemia and 20% participants among control group had hyperuricemia. The mean value of uric acid was significantly higher among cases as compared to control (7.82 v/s 5.02; p<0.001). the odds of occurring hyperuricemia was 2.35 times greater than control. Conclusion: We found a significant correlation between hyperuricemia and hypertension. The odds of occurring hyperuricemia was 2.35 times greater than control.