Intraneural Device for Electrostimulation of Vagus Nerve in Rats: A Feasibility Study for Modulating Glucose Tolerance
EMPATIC treatment is effective in hyperglycemic conditions after glucose intake. No significant effects were observed when VNS was applied under fasting conditions. This study indicated the suitability of applying thin-film intrafascicular electrodes for transversal insertion into small nerves (mean diameter of 400 μm), which, to the best of our knowledge, represents an advancement over the state of the art. It also establishes the feasibility of investigating neural pathways related to glucose homeostasis using invasive intraneural electrodes in the right cervical vagus nerve of rats.
Authors
- Emanuela Pasquali (ORCID: https://orcid.org/0000-0002-3997-0659)
- Emiliano Fratini (ORCID: https://orcid.org/0000-0003-2522-1718)
- Silvia Bossi (ORCID: https://orcid.org/0000-0002-1459-7333)
- Mariateresa Mancuso (ORCID: https://orcid.org/0000-0002-0912-9287)
- Maria Luisa Grilli (ORCID: https://orcid.org/0000-0002-9434-145X)
- Alessandro Zambotti
- Marta Piscitelli
- Caterina Merla (ORCID: https://orcid.org/0000-0001-8612-9566)
Institutions
- National Agency for New Technologies Energy and Sustainable Economic Development (GB)
Publication Details
- Journal
- Neuromodulation Technology at the Neural Interface
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.neurom.2024.10.004
- Citations
- 1
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.25