Effect of silencing Ras homolog family member C on proliferation, invasion, and migration of salivary adenoid cystic carcinoma.
RhoC is highly expressed in SACC, and RhoC silencing may target the downstream ROCK1/p38MAPK/TWIST1 signaling pathway, thereby inhibiting the proliferation, invasion, migration, and EMT of SACC while promoting its apoptosis. On the contrary, miR-138-5p is lowly expressed in SACC and is a potential upstream gene of RhoC, and there may be binding sites between the two genes.
Authors
- Wenyuan Yu (ORCID: https://orcid.org/0000-0002-2917-5993)
- Jin Xu (ORCID: https://orcid.org/0000-0002-2942-8604)
- Chenghao Yu (ORCID: https://orcid.org/0000-0002-2542-944X)
- Yu‐Yun Shao (ORCID: https://orcid.org/0000-0001-7334-1912)
- Qiuping He
- Lei Xie (ORCID: https://orcid.org/0000-0001-9140-8105)
- Peng Zhao (ORCID: https://orcid.org/0000-0002-2218-0941)
- Yong Xu
- Zheng-Gang Chen (ORCID: https://orcid.org/0009-0008-4558-8019)
Institutions
- Qingdao University (CN)
- Shandong University of Aeronautics (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- DOI
- https://doi.org/10.7518/hxkq.2024.2024092
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00