Sex and Common Germline Variants Affect the Toxicity Profile and Pharmacokinetics of Alectinib: A Nationwide Cohort Study in Patients With ALK-Positive NSCLC
Female patients encounter more severe toxicity due to higher alectinib exposure, which warrants further exploration. PPAR-α 209G>A significantly increased relevant alectinib-induced toxicity, most likely due to an increase in alectinib exposure. Pretreatment testing for genetic variants with a subsequent dose reduction could provide a viable approach to reduce alectinib-related toxicity.
Authors
- Lizza Hendriks (ORCID: https://orcid.org/0000-0002-3521-2535)
- Marthe S. Paats (ORCID: https://orcid.org/0000-0003-1602-6195)
- M Benthe Muntinghe-Wagenaar (ORCID: https://orcid.org/0000-0003-3785-7406)
- Alwin D. R. Huitema (ORCID: https://orcid.org/0000-0003-1939-4639)
- Anthonie J. van der Wekken (ORCID: https://orcid.org/0000-0001-7175-0026)
- Anne‐Marie C. Dingemans (ORCID: https://orcid.org/0000-0001-6105-182X)
- N. Heersche (ORCID: https://orcid.org/0000-0003-2913-8989)
- Ezgi B Ulas (ORCID: https://orcid.org/0000-0003-1551-738X)
- Sander Croes (ORCID: https://orcid.org/0009-0003-5799-1415)
- Evert de Jonge (ORCID: https://orcid.org/0000-0002-5775-6488)
- Ron H.J. Mathijssen (ORCID: https://orcid.org/0000-0001-5667-5697)
- Idris Bahce (ORCID: https://orcid.org/0000-0002-1111-608X)
- D. Lanser (ORCID: https://orcid.org/0009-0006-7827-939X)
- Ma Ida Mohmaed Ali (ORCID: https://orcid.org/0000-0002-6853-6763)
- Tessa M A Trooster
- Esther Oomen-de Hoop
- G. Veerman (ORCID: https://orcid.org/0000-0002-4594-3374)
- Ron H. N. van Schaik
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- The Netherlands Cancer Institute (NL)
- Maastricht University (NL)
- Oncode Institute (NL)
- Princess Máxima Center (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Journal of Thoracic Oncology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.jtho.2024.11.025
- Citations
- 4
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.68