Alpha-Lipoic Acid-Mediated Inhibition of LTB4 Synthesis Suppresses Epithelial-Mesenchymal Transition, Modulating Functional and Tumorigenic Capacities in Non-Small Cell Lung Cancer A549 Cells
These findings suggest that ALA may offer therapeutic potential in the context of lung cancer, as it could be integrated into conventional pharmacological therapies to enhance treatment efficacy and mitigate the adverse effects associated with chemotherapy. Further studies are warranted to confirm the clinical applicability of ALA as an adjunctive treatment in lung cancer.
Authors
- Héctor R. Contreras (ORCID: https://orcid.org/0000-0003-4012-2662)
- Alexandra Valle
- Fernanda López‐Moncada (ORCID: https://orcid.org/0000-0002-0810-7684)
- Sebastián Indo
- María José Torres
- Juan Carlos Ríos (ORCID: https://orcid.org/0000-0003-0701-9604)
- Enrique A. Castellón (ORCID: https://orcid.org/0000-0002-3770-8550)
- Mario Faúndez (ORCID: https://orcid.org/0000-0002-5507-3579)
- Kevin Brockway Gv
Institutions
- Universidad de Santiago de Chile (CL)
- Pontificia Universidad Católica de Chile (CL)
- Austral University of Chile (CL)
- University of Chile (CL)
Publication Details
- Journal
- Current Therapeutic Research
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1016/j.curtheres.2024.100765
- Citations
- 1
- Primary Topic
- Biochemical Acid Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- Universidad de Chile
- Agencia Nacional de Investigación y Desarrollo
- Fondo Nacional de Desarrollo Científico y Tecnológico
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias