2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment
MT-ND3 is a crucial target for improving diabetic cognitive dysfunction, and 2-HIBA can directly bind to the MT-ND3 protein to alleviate the functional impairment of the mitochondrial respiratory chain in mice to treat DCI.
Authors
- Tian Lan
- Qi Wang (ORCID: https://orcid.org/0000-0002-0681-6508)
- Shuijie Li (ORCID: https://orcid.org/0000-0003-4538-8996)
- Minzhen Xie
- Yan Liu (ORCID: https://orcid.org/0000-0002-1597-5762)
- Siqi Gu (ORCID: https://orcid.org/0000-0001-5480-4117)
- Jianjia Zhang (ORCID: https://orcid.org/0000-0001-5048-5606)
- Wanying Lu
- Lin Li (ORCID: https://orcid.org/0000-0003-0426-6546)
- Yuqi Wang (ORCID: https://orcid.org/0000-0002-1146-157X)
- Chao He (ORCID: https://orcid.org/0009-0005-2552-5000)
- Wei Yin (ORCID: https://orcid.org/0000-0001-6648-1538)
- Limin Zhao (ORCID: https://orcid.org/0000-0003-2851-6415)
- Yang Hong (ORCID: https://orcid.org/0000-0002-8375-2683)
- Haolin Yang (ORCID: https://orcid.org/0009-0002-4067-6251)
- Heng Liu (ORCID: https://orcid.org/0009-0005-2882-6474)
Institutions
- Harbin Medical University (CN)
- Beijing University of Chinese Medicine (CN)
- Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.redox.2024.103446
- Citations
- 6
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China