Overexpression of endothelial S1pr2 promotes blood–brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models
Our findings identify a previously undisclosed role of S1pr2 in the pathophysiology of TBI. The S1pr2 inhibition presents a novel approach to alleviate BBB disruption after TBI through regulating the JNK/c-Jun/MMP-9 pathway.
Authors
- Jiegang Yu
- Yunpeng Men (ORCID: https://orcid.org/0000-0003-4137-4247)
- Yang Wu (ORCID: https://orcid.org/0000-0001-7173-1757)
- Gengshen Zhang (ORCID: https://orcid.org/0000-0001-9432-0969)
- Jiaming Li (ORCID: https://orcid.org/0000-0003-2141-7561)
- Xiaoliang Wang (ORCID: https://orcid.org/0000-0002-0883-7716)
- Hongbo Cheng (ORCID: https://orcid.org/0000-0002-8816-7109)
- Guozhu Sun
- Yaqing An
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.3389/fphar.2024.1448570
- Citations
- 14
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- Natural Science Foundation of Hebei Province
- Hebei Provincial Health and Family Planning Commission