Genetic engineering of Nannochloropsis oceanica to produce canthaxanthin and ketocarotenoids
Through targeted gene redesign and heterologous transformation, ketocarotenoids and canthaxanthin content were significantly increased, achieving 0.3% and 0.2% dry weight. Canthaxanthin could be produced using CO<sub>2</sub> as the only carbon source at 1.5 mg/L titer. These bkt-engineered lines hold potential for industrial applications in fish or poultry feed sectors, where canthaxanthin and ketocarotenoids are required as pigmentation agents.
Authors
- Sarah D’Adamo
- Flávio Martini (ORCID: https://orcid.org/0000-0003-3196-5713)
- Stefano Cazzaniga (ORCID: https://orcid.org/0000-0002-2824-7916)
- Matteo Ballottari (ORCID: https://orcid.org/0000-0001-8410-3397)
- Davide Canini
- Tea Miotti
- Beatrice Pacenza
Institutions
- University of Verona (IT)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s12934-024-02599-4
- Citations
- 13
- Primary Topic
- Algal biology and biofuel production
- Type
- article
- Field-Weighted Citation Impact
- 1.33
Funders
- HORIZON EUROPE European Innovation Council