A novel <i>in vivo</i> approach to monitoring Cyp3a induction and inhibition by bioluminescent urinalysis
A Cyp3a-selective luminogenic probe substrate enables rapid urinalysis-based testing for detecting Cyp3a induction and inhibition and predicting Cyp3a-dependent DDIs. The study serves as a proof of concept for using caged luciferins for <i>in vivo</i> enzyme activity tests with a readily accessible sample type.
Authors
- Katarina Bohm (ORCID: https://orcid.org/0000-0002-2680-0220)
- Dongping Ma (ORCID: https://orcid.org/0000-0003-0970-8112)
- Dieter H. Klaubert
- James J. Cali
Institutions
- Promega (United States) (US)
Publication Details
- Journal
- Expert Opinion on Drug Metabolism & Toxicology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1080/17425255.2024.2434645
- Citations
- 1
- Primary Topic
- Chemical Reactions and Isotopes
- Type
- article
- Field-Weighted Citation Impact
- 0.21