Radioimmunotherapy combating biofilm-associated infection in vitro
Our findings underscore the effectiveness of [<sup>225</sup>Ac]4497-IgG1 and [<sup>177</sup>Lu]4497-IgG1 antibodies in exerting dose-dependent bactericidal effects against planktonic S. <i>aureus</i> and biofilms <i>in vitro</i>. This suggests that radioimmunotherapy might serve as a promising targeted treatment approach for combating S. <i>aureus</i> and its biofilm.
Authors
- F. Ruben H. A. Nurmohamed (ORCID: https://orcid.org/0000-0001-5369-9853)
- J. Fred F. Hooning van Duyvenbode
- Marnix G. E. H. Lam (ORCID: https://orcid.org/0000-0002-4902-9790)
- Ekaterina Dadachova (ORCID: https://orcid.org/0000-0001-7300-6479)
- Zijian Ye
- Bart C. H. van der Wal (ORCID: https://orcid.org/0000-0002-2554-4675)
- Berend van der Wildt (ORCID: https://orcid.org/0000-0001-5503-2382)
- Harrie Weinans (ORCID: https://orcid.org/0000-0002-2275-6170)
- Jos A. G. van Strijp (ORCID: https://orcid.org/0000-0001-6253-0830)
- Alex J. Poot (ORCID: https://orcid.org/0000-0002-7466-4171)
- H. Charles Vogely (ORCID: https://orcid.org/0000-0002-0934-2985)
Institutions
- University Medical Center Utrecht (NL)
- University of Saskatchewan (CA)
- Delft University of Technology (NL)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-11-29
- DOI
- https://doi.org/10.3389/fmed.2024.1478636
- Citations
- 3
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek