SIRT5 inhibits glycolysis and nasal type extranodal NK/T cell lymphoma cell proliferation by catalyzing the desuccinylation of glucose-6-phosphate isomerase
SIRT5 inhibits glycolysis via catalyzed the desuccinylation of glycolytic enzyme GPI, thereby repressing ENKTL cells proliferation and tumor growth. As SIRT5 serves as a tumor suppressor in ENKTL, it may be a promising molecular target in therapy strategy.
Authors
- Wěi Li (ORCID: https://orcid.org/0000-0002-9522-4474)
- Guohui Liu (ORCID: https://orcid.org/0000-0002-2013-1396)
- Ming Jiang (ORCID: https://orcid.org/0000-0003-1417-360X)
- Qing Xiang (ORCID: https://orcid.org/0000-0003-3423-6807)
- Guolin Tan (ORCID: https://orcid.org/0000-0003-1295-7953)
- Tiansheng Wang (ORCID: https://orcid.org/0000-0001-5073-2670)
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.tranon.2024.102215
- Citations
- 3
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.03
Funders
- Natural Science Foundation of Hunan Province
- Centre National de la Recherche Scientifique