Sex differences in MAGEL2 gene promoter methylation in high functioning autism - trends from a pilot study using nanopore Cas9 targeted long read sequencing
In this pilot study utilizing nanopore Cas9 targeted DNA sequencing, significant sex-specific differences in MAGEL2 gene promoter methylation were identified in male adults with HFA in comparison to control groups, suggesting the potential for sex-specific epigenetic differences. However, further replication in larger cohorts is required to validate these findings.
Authors
- Helge Frieling (ORCID: https://orcid.org/0000-0001-5146-9720)
- Stefan Bleich (ORCID: https://orcid.org/0000-0001-5004-3824)
- Maximilian Deest (ORCID: https://orcid.org/0000-0002-8759-8660)
- Kirsten Jahn (ORCID: https://orcid.org/0000-0002-2760-1602)
- Jelte Wieting (ORCID: https://orcid.org/0000-0001-8572-1365)
Institutions
- Medizinische Hochschule Hannover (DE)
- Lahntalklinik (DE)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s12920-024-02053-9
- Citations
- 2
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.69
Funders
- Deutsche Forschungsgemeinschaft
- Medizinischen Hochschule Hannover