Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease
Our study demonstrated that KLF4 is a crucial regulator of IEB, suggesting that targeting KLF4 may be a promising therapeutic alternative for IBD.
Authors
- Kanger Shen
- H Zhang (ORCID: https://orcid.org/0009-0007-7202-9397)
- Xingchao Zhu
- Jinghan Zhu (ORCID: https://orcid.org/0000-0002-6310-1672)
- Qinhua Xi (ORCID: https://orcid.org/0000-0002-0629-7867)
- Kexi Yang
- Tongguo Shi (ORCID: https://orcid.org/0000-0002-5382-2775)
- Hongqin Yue (ORCID: https://orcid.org/0000-0002-4159-4963)
- Xia Leng
- Jiayu Wang (ORCID: https://orcid.org/0000-0001-5957-4840)
- Juntao Li (ORCID: https://orcid.org/0000-0001-5377-7866)
- Kun Wang (ORCID: https://orcid.org/0009-0005-4052-6909)
Institutions
- Soochow University (CN)
- Yancheng Third People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1007/s00018-024-05514-7
- Citations
- 11
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- Soochow University