<scp>VEXAS</scp> Syndrome: Histiocytoid Cells With Feathery Cytoplasm as a Clue to the Diagnosis
VEXAS (Vacuoles, E1-ubiquitin activating enzyme UBA1 variant, X-linked, Autoinflammatory, Somatic) syndrome was initially described as having mature neutrophil-predominant infiltrates. More recent reports suggest that infiltrates can be composed of variable cell types. We report three cases of VEXAS syndrome with seven total biopsies having in common histiocytoid cells with feathery cytoplasm; these cells may be a potential clue to the diagnosis.
Authors
- Jeff Gehlhausen (ORCID: https://orcid.org/0000-0002-7659-1105)
- Christine J. Ko (ORCID: https://orcid.org/0000-0003-2270-2524)
- Jonathan S. Leventhal (ORCID: https://orcid.org/0000-0002-3757-8477)
- Ian D. Odell (ORCID: https://orcid.org/0000-0003-3990-6929)
- Amanda Zubek (ORCID: https://orcid.org/0000-0003-2237-8007)
- Jennifer Madison McNiff (ORCID: https://orcid.org/0000-0001-8142-6481)
Institutions
- Yale University (US)
Publication Details
- Journal
- Journal of Cutaneous Pathology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1111/cup.14757
- Citations
- 5
- Primary Topic
- Otitis Media and Relapsing Polychondritis
- Type
- article
- Field-Weighted Citation Impact
- 2.35