A catalog of gene editing sites and genetic variations in editing sites in model organisms
Our findings not only revealed the distribution characteristics of editing sites of six representative Cas proteins in ten model organism genomes but also shed light on the adverse effect of variation sites on target site recognition. Our current work will serve as a reminder of the risks of CRISPR application.
Authors
- Jian‐Kang Zhu (ORCID: https://orcid.org/0000-0001-5134-731X)
- Wenfei Jin (ORCID: https://orcid.org/0000-0002-0028-3739)
- Weilong Yang
Institutions
- Southern University of Science and Technology (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Guangzhou Women and Children Medical Center (CN)
- University of Chinese Academy of Sciences (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s12864-024-11073-9
- Citations
- 2
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China