Conformation Influences Biological Fates of Peptide‐Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement

Filamentous structures exert biological functions mediated by multivalent interactions with their counterparts in sharp contrast with spherical ones. The physicochemical properties and unique behaviors of nanofilaments that are associated with multivalent interaction with protein are poorly understood. Here, peptide-based nanofilaments containing different homotetrapeptidic inserts are reported and their protein adsorption and biological fates are tested. By altering the homotetrapeptides, different peptidic conformations are imposed within the nanofilaments, which result in notable differences in the density of the intermolecular hydrogen bond, determining the amount of adsorbed proteins. The adsorbed proteins can further induce interfilament entanglement of different degrees and patterns, which influences biodistribution and phagocytosis. The nanofilaments with tetrahydroxyproline segment exhibit diminish interfilament entanglement, phagocytosis, and improve circulation, biodistribution, and antitumor efficacy. These findings can deepen the understanding of nanofilament-protein interactions and filament-filament interactions as in the case of amyloid-β plaque, and facilitate the rational design of nanofilaments through peptide conformation control for chemical engineering and anticancer drug delivery.

Authors

Institutions

Publication Details

Journal
Advanced Materials
Published
2024-11-28
DOI
https://doi.org/10.1002/adma.202409130
Citations
4
Primary Topic
Supramolecular Self-Assembly in Materials
Type
article
Field-Weighted Citation Impact
0.69

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Conformation Influences Biological Fates of Peptide‐Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement

Junfan Chen, Xiaoting Shan, Linyang Jiang, Binyu Zhu et al.
4 citations
Advanced Materials
Supramolecular Self-Assembly in Materials
0.69
article

Conformation Influences Biological Fates of Peptide‐Based Nanofilaments by Modulating Protein Adsorption and Interfilament Entanglement

Junfan Chen, Xiaoting Shan, Linyang Jiang, Binyu Zhu, Tiantian Xu, Helen He Zhu, Yao Li, Yaping Li, Xin D. Gao, Ying Cai, Rong Rong, Pengcheng Zhang, Yang Yu, Lu Zhang
article en
4 citations

Abstract

Filamentous structures exert biological functions mediated by multivalent interactions with their counterparts in sharp contrast with spherical ones. The physicochemical properties and unique behaviors of nanofilaments that are associated with multivalent interaction with protein are poorly understood. Here, peptide-based nanofilaments containing different homotetrapeptidic inserts are reported and their protein adsorption and biological fates are tested. By altering the homotetrapeptides, different peptidic conformations are imposed within the nanofilaments, which result in notable differences in the density of the intermolecular hydrogen bond, determining the amount of adsorbed proteins. The adsorbed proteins can further induce interfilament entanglement of different degrees and patterns, which influences biodistribution and phagocytosis. The nanofilaments with tetrahydroxyproline segment exhibit diminish interfilament entanglement, phagocytosis, and improve circulation, biodistribution, and antitumor efficacy. These findings can deepen the understanding of nanofilament-protein interactions and filament-filament interactions as in the case of amyloid-β plaque, and facilitate the rational design of nanofilaments through peptide conformation control for chemical engineering and anticancer drug delivery.

Advanced MaterialsVol. 37(3)
Shanghai Jiao Tong University (CN), Chinese Academy of Sciences (CN), ShanghaiTech University (CN), Shanghai Advanced Research Institute (CN), Shanghai Institute of Materia Medica (CN), Fujian Institute of Research on the Structure of Matter (CN), State Key Laboratory of Oncogene and Related Genes (CN), University of Chinese Academy of Sciences (CN), King Abdullah University of Science and Technology (SA)
National Natural Science Foundation of China, Chinese Academy of Sciences, National Key Research and Development Program of China
Good health and well-being
Openalex Percentile: Top 33%
Supramolecular Self-Assembly in Materials
0.69
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.