Single-cell RNA-seq reveals FGF12 as a prognostic biomarker in low-grade endometrial stromal sarcoma
Our study reveals the complexity of TME within the LG-ESS and highlights the role that tumor cell subpopulations play in disease progression and patient prognosis. The identification of <i>FGF12</i> as a prognostic biomarker suggests a new approach for the personalized treatment and prognosis monitoring of patients.
Authors
- Udo S. Gaipl (ORCID: https://orcid.org/0000-0001-6375-5476)
- Ying Cai (ORCID: https://orcid.org/0009-0005-4901-5152)
- Jinjing Wang
- Dan Yuan (ORCID: https://orcid.org/0009-0001-7584-2312)
- Benjamin Frey (ORCID: https://orcid.org/0000-0001-6743-3351)
- Jian‐Guo Zhou (ORCID: https://orcid.org/0000-0002-5021-3739)
- Qiyin Zhou (ORCID: https://orcid.org/0000-0003-3603-8214)
- Julia Thiel (ORCID: https://orcid.org/0009-0003-5437-8498)
- Haitao Wang (ORCID: https://orcid.org/0000-0001-6910-974X)
- Meng Dong (ORCID: https://orcid.org/0000-0002-6434-1678)
- Hu Ma (ORCID: https://orcid.org/0000-0003-1654-1576)
- Miao Yu (ORCID: https://orcid.org/0009-0008-3981-7284)
- Su‐Han Jin (ORCID: https://orcid.org/0000-0001-6203-6285)
- Na Li (ORCID: https://orcid.org/0000-0003-2811-4758)
- Hua Yang
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Zunyi Medical University (CN)
- Universitätsklinikum Erlangen (DE)
- Henan Academy of Sciences (CN)
- Tongren Hospital (CN)
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- Comprehensive Cancer Center Erlangen (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.3389/fimmu.2024.1513076
- Citations
- 5
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China