Global lncRNA expression signature in pre-metastatic lung and their regulatory effects in pulmonary metastasis
Our research delineated the lncRNA expression profiles in pre-metastatic pulmonary tissues and identified, for the first time, the pivotal role of lncRNA Gm5144-202 in modulating M2 macrophage polarization and tumor cell invasiveness. Consequently, targeting lncRNA Gm5144-202 holds substantial promise for translational applications aimed at mitigating pulmonary metastasis.
Authors
- Qin Yan (ORCID: https://orcid.org/0000-0003-4077-453X)
- Lei Chen (ORCID: https://orcid.org/0009-0001-1696-5902)
- Jiaan Wang (ORCID: https://orcid.org/0009-0006-1694-9597)
- Jie Lv (ORCID: https://orcid.org/0000-0001-5071-8959)
- Huifang Shi
- Peng Wang (ORCID: https://orcid.org/0000-0003-1975-7989)
Institutions
- People’s Hospital of Rizhao (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.3389/fimmu.2024.1506561
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00