Combination of gallium citrate and levofloxacin induces a distinct metabolome profile and enhances growth inhibition of multidrug-resistant Mycobacterium tuberculosis compared to linezolid
In the presence of Lfx, the <i>Mtb</i> metabolome changes induced by Ga are more pronounced compared to those observed with Lzd. Lfx affects nucleic acids and transcription, which may enhance Ga-dependent growth inhibition by preventing the metabolic redirection that bacteria typically use to bypass iron-dependent enzymes.
Authors
- Oleksandr Ilchenko (ORCID: https://orcid.org/0000-0001-7343-617X)
- Madeleine Ramstedt (ORCID: https://orcid.org/0000-0003-2646-8501)
- Olena Rzhepishevska (ORCID: https://orcid.org/0000-0002-7912-7447)
- V. O. Іvanytsia (ORCID: https://orcid.org/0000-0001-5325-3800)
- Cristina Prat (ORCID: https://orcid.org/0000-0001-6974-9165)
- Elena Nikolaevskaya
- O. Yu. Zinchenko (ORCID: https://orcid.org/0000-0003-4338-3139)
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- National University Odesa Law Academy (UA)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Umeå University (SE)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.3389/fmicb.2024.1474071
- Citations
- 4
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- Kempe Foundation
- Science for Life Laboratory
- Erasmus+