ZIKV prM hijacks PIM1 kinase for phosphorylation to prevent ubiquitin−mediated degradation and facilitate viral replication
These findings revealed PIM1 as a critical host factor that is advantageous to ZIKV and revealed that targeting the PIM1‒prM axis is a conducive strategy for controlling ZIKV infection.
Authors
- Rui Pang (ORCID: https://orcid.org/0000-0001-9300-6142)
- Yining Lei (ORCID: https://orcid.org/0009-0002-7261-7256)
- Hang Fai Kwok (ORCID: https://orcid.org/0000-0002-6349-4517)
- Yishuo Liu
- Zhijian Cao (ORCID: https://orcid.org/0000-0002-2603-5434)
- Yingliang Wu (ORCID: https://orcid.org/0000-0002-7204-6484)
- Gang Xu (ORCID: https://orcid.org/0000-0001-9203-4803)
- Yingying Ren (ORCID: https://orcid.org/0000-0002-6990-3174)
Institutions
- University of Macau (MO)
- Wuhan University (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (CN)
- Hubei University of Technology (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.3389/fcimb.2024.1502770
- Citations
- 5
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.12