Pediatric adrenocortical tumor manifesting as Cushing’s syndrome and virilization

ABSTRACT Pediatric Cushing’s syndrome is a rare entity. In younger children, adrenocortical tumors are the common cause of this syndrome. Although clinically it is difficult to differentiate benign adrenocortical adenoma from aggressive carcinoma, the categorization of the tumor by the Wieneke scoring system can assist in predicting the future outcomes. In this study, we report a case of a 2-year-old male child diagnosed with endogenous Cushing syndrome and virilization due to a right adrenocortical adenoma. After a successful right adrenalectomy, the child experienced clinical and biochemical improvement, including weight loss and resolution of cushingoid features, with normalization of blood pressure and hyperandrogenism.