Discovery of novel pyrazoline insecticides

We used a chemistry-driven approach to explore position 5 on the pyrazoline core and a computationally-driven approach for bio-isosteric replacement of the aryl amide, leading to two novel pyrazoline sub-classes with improved insecticidal activities and favorable environmental fate profiles compared to PH 60-41 (the Philips Duphar compound). The MoA of these novel sub-classes was also confirmed as block of voltage-dependent sodium channels. © 2024 Society of Chemical Industry.