Qingfei Yin alleviates Streptococcus pneumoniae pneumonia by promoting complete autophagy to suppress necroptosis
This study demonstrated that QFY can effectively alleviate S. pneumoniae pneumonia. The mechanism of action may be that QFY promotes complete autophagy by downregulating p62 expression, thereby alleviating necroptosis of S. pneumoniae-induced lung epithelial cells and reducing lung injury. It provides a scientific basis for clinical prevention and treatment of S. pneumoniae pneumonia.
Authors
- Liping Sun (ORCID: https://orcid.org/0000-0002-3679-4469)
- Jiaqi Wu
- Yiquan Li (ORCID: https://orcid.org/0000-0002-8859-0652)
- Lizhong Ding
- Renshuang Zhao
- Zhigang Xue (ORCID: https://orcid.org/0000-0002-5492-0553)
- Xiaozhou Sun
- Li Xiao (ORCID: https://orcid.org/0000-0002-8929-8047)
- Tangbin Tian
- Zhongtian Wang (ORCID: https://orcid.org/0000-0003-3417-9865)
Institutions
- Yanbian University (CN)
- Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.phymed.2024.156280
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.94