Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD mice
LR3 promotes favorable effects on Aβ plaque remodeling in cortex of male 5XFAD mice but fails to preserve aspects of behavior or memory. While these data do not support LR3 as a monotherapy <i>per se</i>, they do warrant further investigation into its potential for combinatorial formulations aimed at targeting the complexity of AD.
Authors
- Sushma Narayan
- Xusheng Zhang (ORCID: https://orcid.org/0000-0002-9335-5577)
- Matthew G. Engel (ORCID: https://orcid.org/0000-0003-3596-1584)
- Craig A. Branch (ORCID: https://orcid.org/0000-0003-2460-0097)
- Min‐Hui Cui
- Michelle E. Ehrlich (ORCID: https://orcid.org/0000-0001-9397-686X)
- Derek M. Huffman (ORCID: https://orcid.org/0000-0001-9520-3449)
- Sam Gandy (ORCID: https://orcid.org/0000-0001-6455-4721)
Institutions
- Albert Einstein College of Medicine (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1177/13872877241299056
- Citations
- 5
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- National Institutes of Health
- National Institute on Aging
- National Cancer Institute
- National Institute of General Medical Sciences