A <i>DAT1</i> gene and <i>APOE</i> ε4 interaction is associated with apathy and structural brain changes in mild cognitive impairment and Alzheimer's disease
The results point to an association of a dopaminergic genetic marker and apathy in the AD continuum and may inform future design of clinical trials of apathy, as well as new treatment targets.
Authors
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Derek Beaton (ORCID: https://orcid.org/0000-0001-6118-4366)
- Robert A. Hegele (ORCID: https://orcid.org/0000-0003-2861-5325)
- Rubina Malik (ORCID: https://orcid.org/0000-0001-5167-4687)
- Elizabeth C. Finger (ORCID: https://orcid.org/0000-0003-4461-7427)
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Jian Wang (ORCID: https://orcid.org/0000-0002-5974-2602)
- Juweiriya Ahmed
Institutions
- Western University (CA)
- Toronto Public Health (CA)
- University of Toronto (CA)
- Indiana University School of Medicine
- Unity Health Toronto
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1177/13872877241299785
- Citations
- 2
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research