Anti-inflammatory and anti-oxidative effect of pasterurised yoghurt in indomethacin induced gastric ulceration in male Wistar rats

Indomethacin administration resulted in severe ulceration of stomach as well as significant increase in MDA, IL-10, TNF-α and Il-1β. This was accompanied by a significant decrease in GSH, SOD and TAC when compared with control group. Pre-treatment with pasteurized yoghurt caused a significant decrease in the inflammatory parameters and reverse oxidative stress induced by indomethacin administration. Gross and histological observation of the stomach indicate that pre-treated with pasteurized yoghurt offers cytoprotection when compared to indomethacin alone group by reducing inflammation and infiltration of the inflammatory aggregates at the mucosa layer. Therefore, we recommend that the dietary supplementation of pasteurized yoghurt should be encouraged during the treatment of gastric ulcer.