Potential Therapeutic Effects of Ashwagandha) Withania somnifera) plant on Biochemical Changes in Diabetic Rats.

Aim: This study aimed to find out the impact of the various concentrations of ashwagandha plant on biochemical alterations in diabetic rats.Materials and Methods :Thirty adult male albino mice weighing 150±10g, have been utilized & distributed into 2 main groups. The first group (6rats) has been given a basal diet as control (-), the second main group (24 rats) injected with alloxan to cause diabetes, then distributed into four subgroups. One of them was positive diabetes control. Compared to the various three groups, who consumed a basal diet and administered different levels of ashwagandha plant (2.5%, 5%, 7.5%), for 28 days. When the experiment was complete, after treatment with ashwagandha plant, the mice have been weighed & slaughtered, blood samples have been taken, and the serum was separated to do the required measurements. Each FI, BWG & FER were estimated also blood serum glucose, lipide profile, liver function markers, kidney function levels. Results: exhibited that all groups’ values in (HDL-C) showed statistical differences in relation to control (-). While Group 5 was lower value when compared to control (+). Also (ALP)showed groups 5 exhibited statistical variations than control (+). Groups 2 and 3 demonstrated statistical variations than the others.