Investigating the causal relationship between inflammation and multiple types of hearing loss: a multi-omics approach combining Mendelian randomization and molecular docking

This study identified CCL19 as a common risk factor for various types of hearing loss through MR analysis, highlighting the crucial role of inflammatory proteins in hearing loss. The enrichment of related inflammatory proteins in the amygdala and their association with neurodegenerative diseases provide new insights into the mechanisms of hearing loss.

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Publication Details

Journal
Frontiers in Neurology
Published
2024-11-28
DOI
https://doi.org/10.3389/fneur.2024.1422241
Citations
1
Primary Topic
Hearing, Cochlea, Tinnitus, Genetics
Type
article
Field-Weighted Citation Impact
0.36

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article

Investigating the causal relationship between inflammation and multiple types of hearing loss: a multi-omics approach combining Mendelian randomization and molecular docking

Xiangjin Wang, Hui Xie, Jingqi Zhang, Tao Guo et al.
1 citations
Frontiers in Neurology
Hearing, Cochlea, Tinnitus, Genetics
0.36
article

Investigating the causal relationship between inflammation and multiple types of hearing loss: a multi-omics approach combining Mendelian randomization and molecular docking

Xiangjin Wang, Hui Xie, Jingqi Zhang, Tao Guo, Yaxin Chen, Lijiao Wu
article en
1 citations

Abstract

This study identified CCL19 as a common risk factor for various types of hearing loss through MR analysis, highlighting the crucial role of inflammatory proteins in hearing loss. The enrichment of related inflammatory proteins in the amygdala and their association with neurodegenerative diseases provide new insights into the mechanisms of hearing loss.

Frontiers in NeurologyVol. 15
Chengdu Sport University (CN)
National Key Research and Development Program of China
Good health and well-being
Openalex Percentile: Top 38%
Hearing, Cochlea, Tinnitus, Genetics
0.36
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