Investigating the causal relationship between inflammation and multiple types of hearing loss: a multi-omics approach combining Mendelian randomization and molecular docking
This study identified CCL19 as a common risk factor for various types of hearing loss through MR analysis, highlighting the crucial role of inflammatory proteins in hearing loss. The enrichment of related inflammatory proteins in the amygdala and their association with neurodegenerative diseases provide new insights into the mechanisms of hearing loss.
Authors
- Xiangjin Wang (ORCID: https://orcid.org/0000-0002-6798-7300)
- Hui Xie (ORCID: https://orcid.org/0000-0003-2679-2045)
- Jingqi Zhang
- Tao Guo
- Yaxin Chen
- Lijiao Wu
Institutions
- Chengdu Sport University (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fneur.2024.1422241
- Citations
- 1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.36
Funders
- National Key Research and Development Program of China