Research progress on EBV infection and metabolic remodeling

<p indent="0mm">Metabolic alterations driven by viral infection are an important mechanism for viral carcinogenesis. Due to the lack of a complete enzyme system, viruses must rely on the metabolic machinery of host cells. In the long process of evolution, oncogenic viruses change the metabolic pattern of host cells through their own encoded products, which is conducive to the survival of the virus, while meeting the metabolic needs of tumor cells and playing multiple biological effects. Therefore, exploring how viruses affect host cell metabolic pathways in viral infection-related tumors, elucidating the characteristics and mechanisms of metabolic remodeling, and revealing the clinical significance of such metabolic changes will enrich our understanding of viruses and carcinogenesis from a novel perspective, and provide enlightenment for the development of new targeting strategies.

Authors

Publication Details

Journal
Scientia Sinica Vitae
Published
2024-11-29
DOI
https://doi.org/10.1360/ssv-2024-0184
Primary Topic
Cancer, Lipids, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Research progress on EBV infection and metabolic remodeling

Zhe Zhang, Ya Cao
Scientia Sinica Vitae
Cancer, Lipids, and Metabolism
article

Research progress on EBV infection and metabolic remodeling

Zhe Zhang, Ya Cao
article en

Abstract

<p indent="0mm">Metabolic alterations driven by viral infection are an important mechanism for viral carcinogenesis. Due to the lack of a complete enzyme system, viruses must rely on the metabolic machinery of host cells. In the long process of evolution, oncogenic viruses change the metabolic pattern of host cells through their own encoded products, which is conducive to the survival of the virus, while meeting the metabolic needs of tumor cells and playing multiple biological effects. Therefore, exploring how viruses affect host cell metabolic pathways in viral infection-related tumors, elucidating the characteristics and mechanisms of metabolic remodeling, and revealing the clinical significance of such metabolic changes will enrich our understanding of viruses and carcinogenesis from a novel perspective, and provide enlightenment for the development of new targeting strategies.

Scientia Sinica VitaeVol. 54(12)
Openalex Percentile: Top 69%
Cancer, Lipids, and Metabolism
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