Association Between Oxidative Potential of Particulate Matter Collected by Personal Samplers and Systemic Inflammation Among Asthmatic and Non-Asthmatic Adults
With the rationale that the oxidative potential of particulate matter (PM-OP) may induce oxidative stress and inflammation, we conducted the ASTHMA-FENOP study in which 44 asthmatic patients and 37 matched controls wore a personal sampler for 24 h, allowing the collection of fine and coarse PM fractions separately, to determine PM-OP by the dithiothreitol (DTT) and ascorbic acid (AA) methods. The levels of Interleukin 6 (IL-6) and the IL-6/IL-10 ratio, as indicators of pro- and anti-inflammatory statuses, were determined by calculating the mean differences (MDs), odds ratios (ORs) and p-trends adjusted for sex, age, study level and body mass index. Positive associations for IL-6 levels in the form of adjusted MDs and ORs were obtained for all PM-OP metrics, reaching statistical significance for both OP-DTT and OP-AA in the fine fraction, with adjusted OR = 5.66; 95%CI (1.46 to 21.92) and 3.32; 95%CI (1.07 to 10.35), respectively, along with statistically significant dose-response patterns when restricting to asthma and adjusted also for clinical variables (adjusted p-trend = 0.029 and 0.01). Similar or stronger associations and dose-response patterns were found for the IL-6/IL-10 ratio. In conclusion, our findings on the effect of PM-OP on systemic inflammation support that asthma is a heterogeneous disease at the molecular level, with PM-OP potentially playing an important role.
Authors
- Andrea Expósito (ORCID: https://orcid.org/0000-0002-5465-5913)
- Juan Antonio Reyes‐Agüero (ORCID: https://orcid.org/0000-0002-5977-7039)
- Juan José Ruiz-Cubillán (ORCID: https://orcid.org/0000-0002-7251-0232)
- Yolanda Robles
- Ignacio Fernández-Olmo (ORCID: https://orcid.org/0000-0001-6096-5160)
- Esther Barreiro (ORCID: https://orcid.org/0000-0003-2708-3443)
- Carlos Antonio Amado Diago (ORCID: https://orcid.org/0000-0002-5598-1753)
- Juan Luis García‐Rivero (ORCID: https://orcid.org/0000-0002-6407-5832)
- José M. Cifrián (ORCID: https://orcid.org/0000-0003-3682-0142)
- Juan Irure‐Ventura (ORCID: https://orcid.org/0000-0003-2315-8671)
- Marcos López‐Hoyos (ORCID: https://orcid.org/0000-0003-0562-427X)
- Adriana Núñez-Robainas (ORCID: https://orcid.org/0000-0002-5891-5022)
- Miguel Santibáñez (ORCID: https://orcid.org/0000-0003-2634-615X)
- Laura Ruiz-Azcona (ORCID: https://orcid.org/0000-0003-2213-2728)
- Beatriz Abascal-Bolado (ORCID: https://orcid.org/0000-0001-6712-9923)
- Ana Berja
Institutions
- Universidad de Cantabria (ES)
- Universitat Pompeu Fabra (ES)
- Instituto de Salud Carlos III (ES)
- Barcelona Biomedical Research Park (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Marqués de Valdecilla University Hospital (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Municipal Institute for Medical Research (ES)
Publication Details
- Journal
- Antioxidants
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3390/antiox13121464
- Citations
- 3
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Ministerio de Ciencia e Innovación
- Sociedad Española de Neumología y Cirugía Torácica