Palladium-Catalyzed Oxidative Cyclization of <i>O</i>-Aryl Cyclic Vinylogous Esters: Synthesis of Benzofuran-Fused Cyclohexenones
This study presents a method for synthesizing functionalized hydrodibenzofuran derivatives. Using palladium catalysis, <i>O</i>-aryl cyclic vinylogous esters undergo dehydrogenative intramolecular arylation at the vinylic carbon. Preliminary kinetic isotope effect studies suggest that the C(aryl)-H bond cleavage may be the rate-determining step.
Authors
- Ko-Wang Yen (ORCID: https://orcid.org/0000-0002-5702-1967)
- Li‐Ching Shen (ORCID: https://orcid.org/0000-0003-1065-6575)
- Yen‐Ku Wu (ORCID: https://orcid.org/0000-0002-9269-7444)
- Chyh‐Cbung Chein
- Shih-Hsun Wung (ORCID: https://orcid.org/0009-0000-3564-3530)
Institutions
- National Yang Ming Chiao Tung University (TW)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1021/acs.joc.4c02167
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- National Science and Technology Council