The first-in-class bispecific antibody IBI318 (LY3434172) targeting PD-1 and PD-L1 in patients with advanced tumors: a phase Ia/Ib study
IBI318 demonstrated a favorable safety profile and preliminary efficacy in treatment-naïve NSCLC and IO-naïve NPC patients. Further clinical studies are needed to assess the full therapeutic potential of PD-1/PD-L1 dual inhibition with bsAbs.
Authors
- Hongyun Zhao (ORCID: https://orcid.org/0000-0002-1251-3888)
- Wangjun Liao (ORCID: https://orcid.org/0000-0002-1364-8442)
- Yuling Chen
- Hong Pan (ORCID: https://orcid.org/0009-0005-7812-3347)
- Yanqiu Zhao (ORCID: https://orcid.org/0000-0003-0161-6184)
- Xiaoxiao Lu (ORCID: https://orcid.org/0000-0001-8972-431X)
- Furong Liu (ORCID: https://orcid.org/0000-0002-1142-5966)
- Dongmei Ji (ORCID: https://orcid.org/0000-0003-0647-0153)
- Dingzhi Huang
- Kunyu Yang (ORCID: https://orcid.org/0000-0002-2575-4736)
- Hui Zhou (ORCID: https://orcid.org/0009-0000-0642-8663)
- Jian Zhang (ORCID: https://orcid.org/0000-0003-2887-6082)
- Xichun Hu (ORCID: https://orcid.org/0000-0002-2157-2695)
- Dan-Yun Ruan
- Xiao-Li Wei
- Nong Xu (ORCID: https://orcid.org/0009-0001-2545-4370)
- Wen Zhang (ORCID: https://orcid.org/0009-0002-9853-3982)
Institutions
- Union Hospital (HK)
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sir Run Run Shaw Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Zhengzhou University (CN)
- Nanfang Hospital (CN)
- Henan Cancer Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Huazhong University of Science and Technology (CN)
- Southern Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s13045-024-01644-4
- Citations
- 15
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.24
Funders
- Innovent Biologics