Polygenic Prediction of Recurrent Events After Early-Onset Myocardial Infarction
When compared with other clinical risk factors, PGS was the strongest predictor of event recurrence among patients with an early-onset MI. Though the discriminative power of recurrent event prediction in this cohort was modest, the addition of PGS significantly improved discrimination.
Authors
- Antonio Crocamo (ORCID: https://orcid.org/0009-0003-8290-5478)
- Emanuele Di Angelantonio (ORCID: https://orcid.org/0000-0001-8776-6719)
- Rosanna Asselta (ORCID: https://orcid.org/0000-0001-5351-0619)
- Michael C. Honigberg (ORCID: https://orcid.org/0000-0001-8630-5021)
- Giampaolo Niccoli (ORCID: https://orcid.org/0000-0002-3187-6262)
- Libor Pastika (ORCID: https://orcid.org/0000-0001-6892-6553)
- Marco Tubaro (ORCID: https://orcid.org/0000-0003-1702-2401)
- Diego Ardissino (ORCID: https://orcid.org/0000-0003-0410-3528)
- S Bricoli (ORCID: https://orcid.org/0000-0002-6832-8243)
- Samuel A. Lambert (ORCID: https://orcid.org/0000-0001-8222-008X)
- Pradeep Natarajan (ORCID: https://orcid.org/0000-0001-8402-7435)
- Luigi Vignali (ORCID: https://orcid.org/0000-0003-1662-024X)
- Arunashis Sau (ORCID: https://orcid.org/0000-0002-0204-7078)
- Michael Inouye (ORCID: https://orcid.org/0000-0001-9413-6520)
- Adam J. Nelson (ORCID: https://orcid.org/0000-0003-0990-2548)
- Maddalena Ardissino (ORCID: https://orcid.org/0000-0002-2654-8117)
- Martin Kelemen (ORCID: https://orcid.org/0000-0002-4050-1817)
- Giuseppe Maglietta (ORCID: https://orcid.org/0000-0003-4497-1872)
- Lois G. Kim (ORCID: https://orcid.org/0000-0002-4552-3820)
- Antonio de Marvao (ORCID: https://orcid.org/0000-0001-9095-5887)
- Fu Siong Ng (ORCID: https://orcid.org/0000-0002-8681-4368)
- Elvezia Maria Paraboschi (ORCID: https://orcid.org/0000-0002-7935-798X)
- Adam S. Butterworth (ORCID: https://orcid.org/0000-0002-6915-9015)
- Giulia Magnani (ORCID: https://orcid.org/0000-0002-2852-3474)
Institutions
- Broad Institute (US)
- University of Parma (IT)
- Humanitas University (IT)
- Baker Heart and Diabetes Institute (AU)
- British Heart Foundation (GB)
- National Institute for Health and Care Excellence (GB)
- Massachusetts General Hospital (US)
- Departamento de Epidemiología (GT)
- Società Italiana di Cardiologia (IT)
- Women's & Children's Health Research Institute (AU)
- Ospedale San Filippo Neri (IT)
- Lung Institute (US)
- Human Technopole (IT)
- Wellcome Connecting Science (GB)
- Department of Public Health (US)
- MRC London Institute of Medical Sciences (GB)
- IRCCS Humanitas Research Hospital (IT)
- The University of Adelaide (AU)
Publication Details
- Journal
- Circulation Genomic and Precision Medicine
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1161/circgen.124.004687
- Citations
- 2
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- American Heart Association
- Health and Care Research Wales
- Scottish Government
- UK Research and Innovation
- Cancer Research UK
- National Institute for Health and Care Research
- British Heart Foundation
- Public Health Agency
- Fetal Medicine Foundation
- Regione Emilia-Romagna
- Chief Scientist Office, Scottish Government Health and Social Care Directorate
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Economic and Social Research Council
- Health and Social Care Research and Development Division
- NIHR Imperial Biomedical Research Centre
- NIHR Cambridge Biomedical Research Centre
- National Heart, Lung, and Blood Institute
- National Human Genome Research Institute