A polycomb group protein EED epigenetically regulates responses in lipopolysaccharide tolerized macrophages
Our results provided mechanistic insight into how the PRC2 via EED regulates LPS tolerance in macrophages by epigenetically silencing genes that play a crucial role during LPS tolerance such as those of the TGF-β/Runx3 axis.
Authors
- Patipark Kueanjinda (ORCID: https://orcid.org/0000-0003-3581-7013)
- Benjawan Wongprom
- Thitiporn Pattarakankul
- Junichiro Takano
- Supawadee Umthong (ORCID: https://orcid.org/0000-0001-7394-0990)
- Salisa Benjaskulluecha
- Kittitach Sri-ngern-ngam (ORCID: https://orcid.org/0009-0001-5268-5123)
- Tanapat Palaga (ORCID: https://orcid.org/0000-0001-8734-6626)
- Atsadang Boonmee
- Haruhiko Koseki (ORCID: https://orcid.org/0000-0001-8424-5854)
Institutions
- Siriraj Hospital (TH)
- Chulalongkorn University (TH)
- Mahidol University (TH)
- RIKEN Center for Integrative Medical Sciences (JP)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s13072-024-00562-6
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Chulalongkorn University
- Thailand Science Research and Innovation
- RIKEN