A Copper-Catalyzed Synthesis of Pyridoquinazolinones via C(sp<sup>2</sup>)–H Functionalization and Annulation of Benzoic Acids with 2-Aminopyridines
A facile synthesis of pyridoquinazolinones has been accomplished via C(sp<sup>2</sup>)-H functionalization and annulation of benzoic acids with 2-aminopyridines using Cu(OAc)<sub>2</sub> as catalyst in DMSO. The reaction involves the formation of amides which on <i>ortho</i> amination followed by <i>trans</i>-amidation afford a wide array of products under ligand/base-free conditions.
Authors
- Mahesh Kumar
- Km Ishu
- Krishna Nand Singh (ORCID: https://orcid.org/0000-0001-9147-5463)
- Anup Sharma (ORCID: https://orcid.org/0000-0003-2691-5738)
Institutions
- Banaras Hindu University (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1021/acs.orglett.4c03905
- Citations
- 7
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- Banaras Hindu University
- Science and Engineering Research Board