Uncovering immune cell-associated genes in breast cancer: based on summary data-based Mendelian randomized analysis and colocalization study
In summary, our research has revealed a repertoire of genes within diverse immune cells associated with breast cancer. KCNN4 gene in non-classical MONOcytes (MONOnc) exhibited a negative association with overall breast cancer and its subtypes, which was identified as a potential drug target for breast cancer, opening up new avenues for therapeutic interventions.
Authors
- Deqiang Zheng (ORCID: https://orcid.org/0000-0002-5659-5045)
- Jianguang Ji (ORCID: https://orcid.org/0000-0003-0324-9496)
- Lijuan Wu (ORCID: https://orcid.org/0000-0002-5761-5140)
- Ning Li (ORCID: https://orcid.org/0000-0002-6518-2541)
- Jingyang Liu (ORCID: https://orcid.org/0000-0002-1579-825X)
- Haibin Li (ORCID: https://orcid.org/0000-0001-7690-9518)
- Yi Huan (ORCID: https://orcid.org/0000-0002-3936-5264)
- Wen Sun
Institutions
- Fujian Medical University (CN)
- Capital Medical University (CN)
- University of Macau (MO)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s13058-024-01928-0
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Vetenskapsrådet