Palladium-Catalyzed Coupling of Aryl Chlorides with Secondary Phosphines to Construct Unsymmetrical Tertiary Phosphines
The functionalization of the C-Cl bond in unactivated aryl chlorides under mild conditions presents a significant challenge. We disclose a general protocol for constructing both partially and entirely unsymmetrical tertiary phosphines through the Pd/keYPhos-catalyzed coupling of aryl chlorides with secondary phosphines under mild conditions. The reaction exhibits excellent functional group tolerance and broad substrate scopes. Furthermore, the rapid synthesis of ligands and luminescent compound sTPPs, alongside gram-scale systhesis, demonstrates the practical applicability of this method.
Authors
- Yuxuan Xiao (ORCID: https://orcid.org/0000-0002-7332-6568)
- Lin Yu (ORCID: https://orcid.org/0000-0002-1668-4422)
- Xun Yang (ORCID: https://orcid.org/0000-0003-2113-5839)
- Haiyan Li (ORCID: https://orcid.org/0000-0001-8022-3447)
- Wengui Duan (ORCID: https://orcid.org/0000-0001-8140-0011)
- Ying Yin (ORCID: https://orcid.org/0000-0003-2156-4588)
- Jing Liang (ORCID: https://orcid.org/0000-0001-5533-2107)
- Jiahui Du (ORCID: https://orcid.org/0000-0003-3082-6826)
Institutions
- Guangxi University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1021/acs.orglett.4c03951
- Citations
- 14
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region