Integrating Circle-Seq with transcriptomics reveals genome-wide characterization of extrachromosomal circular DNA for dilated cardiomyopathy
Our work provided a detailed profiling of eccDNAs in both healthy and DCM hearts and demonstrated the potential functions of both large and small eccDNAs. These findings enhance the comprehension of the role of eccDNAs in cardiac pathophysiology and establish a theoretical foundation for future investigations on eccDNAs in DCM.
Authors
- Changqian Wang (ORCID: https://orcid.org/0000-0002-7611-7761)
- Fangjie Dai
- Yongchao Zhao (ORCID: https://orcid.org/0000-0003-4610-4182)
- Bo Li (ORCID: https://orcid.org/0000-0002-8617-900X)
- Zhenhao Lin (ORCID: https://orcid.org/0000-0002-7843-3530)
Institutions
- Guiyang Medical University (CN)
- Zunyi Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Renji Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Zhongshan Hospital (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s13062-024-00556-0
- Citations
- 4
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Postdoctoral Program for Innovative Talents