Green Synthesis of Prunus Dulcis (Almond Gum) Capped Silver Nanoparticles Enhancing In Vivo Wound Healing Potential: Comprehensive Review

The rising demand for sustainable and biocompatible materials in biomedical applications has led to significant interest in green-synthesized nanoparticles. This review explores the green synthesis of silver nanoparticles (AgNPs) using Prunus dulcis (almond gum) as a natural capping and stabilizing agent, with a focus on their potential to enhance in vivo wound healing. Almond gum, a natural biopolymer, offers numerous benefits, including biodegradability, water solubility, and bioactivity, which improve the stability and biocompatibility of AgNPs while reducing environmental impact. The unique properties of almond gum-capped AgNPs, such as enhanced antimicrobial efficacy, anti-inflammatory effects, and antioxidant activity, make them particularly advantageous for wound healing applications. We analyze the mechanisms through which AgNPs promote wound repair, including bacterial inhibition, collagen synthesis, and angiogenesis, while mitigating oxidative stress and inflammation. Furthermore, in vivo studies demonstrate accelerated wound closure, reduced infection, and minimized inflammation, underscoring the clinical potential of these biogenic nanoparticles. This review also addresses current challenges, such as production scalability, nanoparticle consistency, and the need for comprehensive toxicity studies to optimize AgNPs for medical use. The findings indicate that almond gum-capped AgNPs represent a promising, eco-friendly alternative for wound care, contributing to advances in regenerative medicine through sustainable nanotechnology.