Lily extract ameliorate mouse pneumonia by modulating ciliary function

This study explores the biological effects and mechanisms of Lily extract on LPS-induced pneumonia mice. Research has found that after 48 h of treatment with low-dose and high-dose lily extract (100 mg/kg, 200 mg/kg), there was a significant reduction in inflammatory cell infiltration, mRNA expression levels of pro-inflammatory factors ( IL-6, IL-1β, TNF-α ), protein levels of inflammation-related proteins (IL-6, NF-κB P65) in the lung tissue. In addition, lily extract significantly improved the function of cilia assembly and movement. The expression levels of cilia-related genes ( Ttc21a, Cfap45, etc.) and proteins were significantly upregulated. Among them, the high-dose treatment group had tightly arranged cilia and good growth conditions, which was significantly better than the LPS pneumonia model and low-dose treatment group. This found providing novel insights into the pathogenesis and progression of pneumonia. This has important implications for the prevention and treatment of pneumonia, as well as the development of natural agents. • Lily extract reduced inflammatory cell infiltration and factors expression in lung. • Lily extract significantly improved the function of cilia assembly and movement. • Lily extract has important implication for prevention and treatment of pneumonia. • LPS combined with tracheal instillation was applied for pneumonia mice modeling.