The regulatory action of acetylcholine and its receptors on B4 and C4 leukotriene formation in the porcine endometrium after experimental inflammogenic <i>Escherichia coli</i> infection
In the inflamed pig endometrium, ACh increased 5-LO, LTAH and LTCS protein abundances and LTB4 and LTC4 release by M3R, and LTCS protein abundance and LTB4 release also by M2R. By interaction with α-7 nAChR, ACh reduced LTAH and LTCS protein abundances and the release of these LTs. Thus, in an indirect manner, ACh can affect LT-controlled processes.
Authors
- D W Kawka
- Jarosław Całka (ORCID: https://orcid.org/0000-0003-4679-5737)
- Barbara Jana (ORCID: https://orcid.org/0000-0001-6508-2965)
- Michał Bulc (ORCID: https://orcid.org/0000-0002-1402-5423)
Institutions
- InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences (PL)
- University of Warmia and Mazury in Olsztyn (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Journal of Veterinary Research
- Published
- 2024-11-29
- DOI
- https://doi.org/10.2478/jvetres-2024-0066
- Citations
- 1
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.64