Dibromomethane-Triggered Electrochemical Cyclization of Enaminones with Amidines for the Synthesis of 5-Acylimidazoles
An electrochemical tandem cyclization of enaminones with amidines has been reported for the first time using dibromomethane as an initiating agent in an undivided cell. Following this protocol, a vast variety of polysubstituted 5-acylimidazoles were obtained in moderate to good yields without the use of external oxidants. Mechanistic studies indicate that the bromide anion, electroreductively generated from dibromomethane, acts as a redox mediator to complete the catalytic cycle.
Authors
- Xingwang Hu (ORCID: https://orcid.org/0000-0002-2320-3279)
- Hui Xu (ORCID: https://orcid.org/0000-0003-3697-9612)
- Zeng‐Yang He
- Pinhua Li (ORCID: https://orcid.org/0000-0002-8528-8087)
- Luan-Ting Wu
- Ze Zhang (ORCID: https://orcid.org/0000-0001-9763-4592)
- Peng Xu (ORCID: https://orcid.org/0000-0002-0078-7742)
- Siqi Chen (ORCID: https://orcid.org/0000-0002-9498-3823)
Institutions
- China Tobacco (CN)
- Anhui Polytechnic University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1021/acs.joc.4c02507
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- Natural Science Foundation of Anhui Province